Séminaire : Regulation of multiciliogenesis by non coding RNAs

Dr. Pascal BARBRY, directeur de l'Institut de Pharmacologie Moléculaire et Cellulaire (CNRS/UNSA UMR7275) à Sophia Antipolis fera une présentation de ses travaux de recherche, Jeudi 13 Juillet 2017 à 11h00 dans les locaux de l'équipe CSTB.
Le bâtiment est situé au 11 rue Humann sur le campus de la Faculté de Médecine de Strasbourg dans la salle 549 au 5ème étage du bâtiment 3.

Titre : Regulation of multiciliogenesis by non coding RNAs

Résumé : The airway mucociliary epithelium, often affected in these diseases, is constituted of basal, mucus-secreting and multiciliated cells (MCCs). As a first line of defense of the organism, it develops complex interactions with the surrounding connective tissue, the immunological environment and the microbiote. By working on the biogenesis of MCCs (i.e. multiciliogenesis), which leads to the formation of hundreds of motile cilia, we have delineated complex relationships between the miR-34/449 microRNA families and several cellular pathways (Notch, BMP, cell cycle, apical actin regulatory network). To define the identities and contributions of important MCC players at different time points of differentiation, we are now developing a single cell RNA sequencing approach that we are applying to 3D cultures of human airway epithelium. I will describe these results.