Seminar : Regulation of multiciliogenesis by non coding RNAs

Dr. Pascal BARBRY, director of the Institute of Molecular and Cellular Pharmacology (CNRS/UNSA UMR7275) at Sophia Antipolis will give a talk on Thursday, July 13th at 11:00 a.m. in the building 3 on the 5th floor, room 549 of the Faculty of Medicine (11 rue Humann in strasbourg).

Team : CSTB

Title : Regulation of multiciliogenesis by non coding RNAs

Abstract : The airway mucociliary epithelium, often affected in these diseases, is constituted of basal, mucus-secreting and multiciliated cells (MCCs). As a first line of defense of the organism, it develops complex interactions with the surrounding connective tissue, the immunological environment and the microbiote. By working on the biogenesis of MCCs (i.e. multiciliogenesis), which leads to the formation of hundreds of motile cilia, we have delineated complex relationships between the miR-34/449 microRNA families and several cellular pathways (Notch, BMP, cell cycle, apical actin regulatory network). To define the identities and contributions of important MCC players at different time points of differentiation, we are now developing a single cell RNA sequencing approach that we are applying to 3D cultures of human airway epithelium. I will describe these results.